Trigun Vash the Stampede and Nicholas D. Wolfwood

Vash the Stampede and Nicholas D. Wolfwood both serves as the protagonists for Japanese action manga series Trigun. Vash the Stampede is a mysterious, wandering gunman also known as The Humanoid Typhoon due to the destruction and chaos which surrounds him. Wielding a huge silver revolver, he travels from town to town. He is initially discovered by Meryl Stryfe and Milly Thompson, two Bernardelli Insurance Society representatives investigating claims made due to damages caused by the mysterious Humanoid Typhoon. Nicholas D. Wolfwood is a priest who wields a large cross-shaped gun named the Punisher, which he and his former colleagues use either in saving people or for complete destruction.

Vash and Wolfwood's relationship throughout the manga is one of the most prominent and important dynamics of the story. Initially sent by Vash's brother, Knives, to act as Vash's "guide", the bond the two develop over the course of the manga strengthens into a genuine partnership and friendship. The two characters eventually are able to recognize and understand each others' emotions, despite their differing principles. While Vash — a gunslinger whose rumored to be a "Humanoid Typhoon" and an indiscriminate cold-blooded killer — harbors a pacifistic philosophy to a detrimental degree, Wolfwood — a travelling priest — violates the "Thou Shalt Not Kill" principle and settles to kill others whenever necessary for the sake of self-preservation or to otherwise protect Vash.